Pharmacogenetics in Clinical Practice

Pharmacogenetics and its relevance to clinical practice.

1Laboratory of Clinical Pharmacology, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore 2SingHealth Clinical Pharmacology Core, The Academia, Singapore General Hospital, Singapore 3Offi ce of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore Address for Correspondence: Prof Balram Chowbay, Division of Medical Sciences, Humphrey Oei Institute of Cancer Res...

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice.

The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. ...

Pharmacogenetics in Practice Pharmacogenetics in Cardiology: Forays into Modern Practice

When one discusses pharmacogenetics in cardiology practice, it is almost obligatory to discuss clopidogrel. Clopidogrel is an antiplatelet used for acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) with stenting, and as secondary stroke prevention in patients with aspirin allergy, among other indications. Clopidogrel is a prodrug that must be metabolized through the cytoch...

Pharmacogenetics for oncology practice.

Pharmacogenetics: transforming clinical medicine.

Pharmacogenetics, the study of genetic variation relevant to drug metabolism, is a rapidly evolving area of medicine. This brief review will consider some of the recent advances where inherited genetic variants have been associated with either drug efficacy or toxicity. Examples of where pharmacogenetic testing has been adopted into clinical practice will be provided as well as a look at its li...